TB-500 is a synthetic laboratory analog of the naturally occurring peptide Thymosin Beta-4. It is characterized by its low molecular weight and its role as a primary G-actin sequestering peptide. In research settings, it is utilized to study cellular motility and the biochemical pathways involved in the structural reorganization of the cytoskeleton.

Key Research Focus Areas:

Actin Polymerization Dynamics: Studied for its ability to bind to G-actin, inhibiting its polymerization into F-actin to observe changes in cellular structural plasticity.
Angiogenesis Signaling Models: Investigated for its role in promoting endothelial cell migration and the formation of tube-like structures in vitro.
MMP (Matrix Metalloproteinase) Regulation: Evaluated for its impact on the expression of enzymes responsible for remodeling the extracellular matrix.
Cellular Chemotaxis: Research focused on the peptide’s ability to act as a signaling molecule for the recruitment of progenitor cells to localized areas of interest.

Technical Details:

Purity: 99%+
Form: Lyophilized peptide
Vial Content: 2mg | 5mg | 10mg
Storage: Store at -20°C for long-term stability; refrigerate at 2–8°C upon arrival for short-term use.
Reconstitution: Bacteriostatic water
Solubility: Highly soluble in aqueous solutions.